The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus
نویسندگان
چکیده
Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.
منابع مشابه
Genetic Diversity in the Collaborative Cross Model Recapitulates Human West Nile Virus Disease Outcomes
UNLABELLED West Nile virus (WNV) is an emerging neuroinvasive flavivirus that now causes significant morbidity and mortality worldwide. The innate and adaptive immune responses to WNV infection have been well studied in C57BL/6J inbred mice, but this model lacks the variations in susceptibility, immunity, and outcome to WNV infection that are observed in humans, thus limiting its usefulness to ...
متن کاملThe Innate Immune Playbook for Restricting West Nile Virus Infection
West Nile virus (WNV) is an emerging mosquito-borne flavivirus that causes annual epidemics of encephalitic disease throughout the world. Despite the ongoing risk to public health, no approved vaccines or therapies exist for use in humans to prevent or combat WNV infection. The innate immune response is critical for controlling WNV replication, limiting virus-induced pathology, and programming ...
متن کاملPrevalence of West Nile Virus Infection in the Cities of Neka and Shiraz, Iran
Abstract Background and Objective: West Nile virus (WNV) is a member of the genus Flavivirus that can cause viral infections in human. This study aimed at detecting IgG antibodies against WNV in patients of two cities of Neka and Shiraz. Material and Methods: the participants were 46 possible WNV case from Neka (13 women and 10 men) and Shiraz (10 women and 13 men). IgG assay was ...
متن کاملAserological survey on antibodies against West Nile virus in horses of Khuzestan province
BACKGROUND: West Nile virus (WNV) is a vector-borneagent that is maintained within a bird-mosquito cycle. In humansand equids, infection by this agent is usually asymptomatic, orcharacterized by a mild febrile illness. However, fatal meningoencephalitisor encephalitis may occur. OBJECTIVES:The aim ofthis study was to evaluate the prevalence of WNVinfection andcorrelation of this organism with h...
متن کاملVaccination against Mosquito Borne Viral Infections: Current Status
Mosquito borne infectious diseases are among important group of diseases worldwide. Vaccination is available for some tropical mosquito-borne diseases, especially for Japa-nese encephalitis virus infection and yellow fever. There are also several attempts to develop new vaccines for the other mosquito-borne diseases such as malaria, dengue infection and West Nile virus infection. In this articl...
متن کامل